In 2005, Miller was cast as Michael Scofield in Fox Network's television drama Prison Break.He played the role of a caring brother who created an elaborate scheme to help his brother, Lincoln Burrows (Dominic Purcell) escape death row after being found guilty of a crime he did not commit.
I needed it like I needed air, it was just something I had to do." Miller's first TV appearance was as student-turned-sea monster Gage Petronzi on Buffy the Vampire Slayer ("Go Fish", 1998).
Miller's first starring role was in 2002 as the sensitive, introverted David Scott in ABC's mini-series Dinotopia.
While at Princeton, he performed with the a cappella group the Princeton Tigertones, and was a member of the Quadrangle Club and the Colonial Club.
He has stated that his rocky road to stardom "was a long time in the coming and there were a lot of upsets and a lot of failures and roadblocks, but I couldn’t walk away from it.
He can carry a whole show in his should and make it a huge hit.